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☆ Down syndrome families' fight for access to Alzheimer’s trials, treatments
▼ + stars: | 2023-10-10 | by ( Julie Steenhuysen | ) www.reuters.com time to read: +9 min

In an extended portion of Eisai’s main Leqembi trial, CAA was associated with one death. 'THE DIGNITY OF RISK'Hillerstrom said the groups are "very strongly" lobbying Eisai and Lilly to conduct the safety trials in Down syndrome, and said he has been meeting with the companies to push them to design such trials. Lilly declined to comment on whether it is considering either a safety trial or taking part in that study. An Eisai spokeswoman said the company "has no immediate plans" to conduct clinical trials of Leqembi in people with Down syndrome. The company is collaborating with LuMind in a study gathering data on how Alzheimer's manifests in people with Down syndrome.

Persons: Oskar Hillerstrom, Lianor, Hampus, Brian Snyder, Lianor da Cunha, Oskar, de Oeiras, Teresa, Oskar’s, Hampus Hillerstrom, Eli Lilly's, LuMind, Hillerstrom, Lilly, Emily Largent, Beau Ances, Louis, I've, Ances, I'm, Michael Rafii, William Mobley, Mobley, Dawn Brooks, donanemab, Margot Rhondeau, Hannah, Julie Steenhuysen, Caroline Humer, Bill Berkrot Organizations: REUTERS, Rights, Reuters, CAA, University of Pennsylvania Perelman School of Medicine, Medicare, U.S . Food, Drug Administration, Washington University, National Institute, Aging, University of Southern, UC San Diego School of Medicine, LuMind, Syndrome, Thomson Locations: Lexington , Massachusetts, U.S, Santo, Portugal, United States, St, University of Southern California

☆ Hot flashes are more dangerous than previously thought
▼ + stars: | 2023-09-27 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +6 min

Welcome to the hot flashes and other symptoms of approaching menopause — an experience experts say about 75% of women will share if they live long enough. Intense hot flashes could indicate an increased risk of Alzheimer's and heart disease in the future, new research found. The women were also fitted with sweat monitors to record their hot flashes on one of those nights. Frequent moderate to severe hot flashes can often last seven to 10 years, on average, and less frequent or severe hot flashes can last even longer, according to experts. “A lot of people actually underreport their hot flashes, saying they’re not having many when they really are,” Faubion said.

Persons: Peter Dazeley, ”, Stephanie Faubion, Faubion, Rebecca Thurston, “, Thurston, ” Faubion, they’ve, Thurston’s, they’re, Mary Carson Organizations: CNN, Bank, Getty, Mayo, Specialty Clinic, “, University of Pittsburgh’s Pitt Public Health, University of Pittsburgh Locations: Philadelphia, Jacksonville , Florida

But Mintz also acknowledges that having more places to access PrEP likely will not be enough to substantially increase its use in more vulnerable communities. “There needs to be a couple of levers that need to be pulled for everybody to access PrEP who are eligible to access PrEP,” Mintz says. (Joe Raedle/Getty Images)Meanwhile, a pending ruling in a federal appellate court looms as a threat that could more broadly undermine PrEP coverage. “We don’t know what the 5th Circuit could do.”In the wake of the March court ruling, insurers expressed support for preventive services. “Right now, PrEP uptake is quite good among gay white men, but among people of color and among women PrEP access is quite limited,” Dawson says.

Persons: Apretude, ”, Omar Martinez Gonzalez, Sean Bland, we’re, ” Bland, Truvada, ” Martinez Gonzalez, Laura Mintz, Mintz, ” Mintz, Truvada –, AIDSVu, Joe Raedle, Laurie Sobel, “, ” Sobel, Lindsey Dawson, ” Dawson, Torrian Baskerville, Baskerville, ” Baskerville, who’d, Biden, Bland Organizations: U.S . Preventive Services Task Force, U.S . Food, Drug Administration, Affordable, AIDS Foundation Chicago, “, Centers for Disease Control, Santa Clara University School of Law, Georgetown University’s O’Neill Institute for National, Global Health, Blacks, PrEP, Emory University, Gilead Sciences, Black PrEP, Case Western Reserve University School of Medicine, Pride Network of, ViiV Healthcare, GlaxoSmithKline, U.S, Circuit, Appeals, Supreme, Human Rights, Navigators, Department of Health, Human Services Locations: U.S, Black, Cleveland, Gilead, –, Miami, Texas, Ohio

☆ Eye-tracking tool may help diagnose autism more quickly and accurately, new studies suggest
▼ + stars: | 2023-09-05 | by ( Jacqueline Howard | Deidre Mcphillips | ) edition.cnn.com time to read: +10 min

But now, two studies released Tuesday suggest that a recently developed eye-tracking tool could help clinicians diagnose children as young as 16 months with autism – and with more certainty. She was not involved in the new studies, but her research focuses on early diagnosis of autism. The children were enrolled in the study between April 2018 and May 2019, and the eye-tracking tool was included in the assessments. Among the children, 335 had an autism diagnosis that their clinicians were “certain” of without using the eye-tracking tool. “There remains work to be done before an eye-tracking test is used in clinical practice.

Persons: ”, Warren Jones, Rather, ’, Whitney Guthrie, Guthrie, “ They’re, ” Jones, –, Ami Klin, Marcus, ” Klin, Kristin Sohl, ” Sohl, Sohl, Dr, Sanjay Gupta, Geraldine Dawson, “, ” Dawson Organizations: CNN, Marcus Autism, Children’s Healthcare, Autism, Emory University School of Medicine, US Food and Drug Administration, Children’s, Philadelphia’s Center, Autism Research, JAMA, Marcus Autism Center, University of Missouri School of Medicine, American Academy of Pediatrics, US Centers for Disease Control, Devices, Get CNN, CNN Health, Duke Center for Autism, Brain Locations: Atlanta, United States, –, North Carolina

Overall, an FDA spokesperson says that “trial participants should reflect the population that is likely to use the product if FDA-approved. Across a group of 10 novel cancer therapies approved by the FDA in 2022, data shows the share of Black participants in key clinical trials ranged from zero to 8%. “Access to clinical trials at the sites where patients are living is an important factor to changing the landscape,” Perez says. “There’s been some novel ways to recruit patients, like using the church and using barbershops to recruit Black patients,” Cho says. Haddad says a number of Mayo patients were receiving experimental therapies through clinical trials when the pandemic began.

Persons: ”, Leslie Cho, Robert, Suzanne Tomsich, it’s, Edith Perez, Bolt Biotherapeutics, ” Perez, Eli Lilly, “, Lilly “, they’ll, Craig Lipset, ” Lipset, ” Cho, “ There’s, Dr, Tufia Haddad, Haddad, Mayo, Jennifer Dahne, Larry Hawk, Hawk Organizations: Women’s Cardiovascular, Cleveland Clinic, of Cardiovascular Medicine, U.S . Food, Drug Administration, FDA, “, Health, Committee, Cancer, Janssen Pharmaceuticals, Centers for Disease Control, Research Alliance, Mayo Clinic Comprehensive Cancer Center, Care, Mayo’s Center for Digital Health, College of Medicine, Medical University of South, of Psychology, University, Buffalo, SUNY, JAMA Locations: U.S, Chicago, Dallas, Los Angeles, Philadelphia, Los Angeles County, Alaska, “, Medical University of South Carolina

CARE Hospitals Group, according to another investor source, is in talks to sell a 70% stake to U.S. investment giant Blackstone (BX.N) in a deal valued at $800 million. MORE ATTRACTIVE THAN EVERAs government hospitals became increasingly overburdened and incomes rose in India's vast middle class, demand for private healthcare rose over the years. "The India healthcare opportunity has always been attractive, but never more than now. In 2022, PE investors spent $3.2 billion buying stakes in hospitals in India. "Big private hospitals are more reliable," said 35-year-old G. Chavan said as he accompanied his wife to see a doctor.

Persons: Rana Mehta, PwC's, Atlantic, Indira, Blackstone, Gaurav Sharma, Investcorp, Nishant Sharma, Sharma, Chavan, Sriram, Aditya Kalra, Simon Cameron, Moore Organizations: PwC, General Atlantic, CARE Hospitals, Blackstone, CARE, Kedaara Capital, ASIA'S PACE, Temasek, Reuters Graphics, Apollo Hospitals, Thomson Locations: India, PUNE, Pune, Indira, Bahrain, Mumbai, Manipal, Asia

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